Growth Hormone MK 677 ( 60 Capsules )

Mk-677 is a growth hormone secretagogue originally developed by Reverse Pharmacology. A secretagogue is a substance that causes another substance to be secreted. So in this case, mk-677 signals the pituitary gland to secrete growth hormone. Mk-677 could be compared to secretagogue peptides like GHRP-6 or Ipamorelin, only it doesn’t require injections. Mk-677 was originally developed for the treatment of elderly patients to combat muscle wasting, obesity and osteoporosis. Although commonly referred and sold as a Selective Androgen Receptor Modulator (SARM), Mk-677 is actually not a SARM and is non-hormonal. As a result, Mk-677 does not affect natural testosterone production or the Hypothalamus-Pituitary-Testes-Axis (HPTA). This means that no post cycle therapy (PCT) is needed after Mk-677 usage and that Mk-677 can be safely included into PCTs and bridges between steroid cycles. Mk-677 works via 4 main mechanisms: 1. Increasing GHRH (growth hormone releasing hormone). 2. Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland. 3. Reducing somatostatin release (somatostatin turns off GH release). 4. Inhibiting of somatostatin receptor signaling. In a mk-677 trial that studied its effects on catabolic states, a daily dosage of 25mgs was given to healthy young men subjected to short-term diet-induced nitrogen wasting. After 7 days of this dose, the subjects showed a sustained increase in serum concentration of IGF-1 and Growth Hormone. In addition, the nitrogen wasting was reversed. Trials testing the effects of mk-677 on fighting obesity showed an increase in lean body mass. This study gave subjects 25mgs of Mk-677 per day for 8 weeks. The subjects saw an increase in basal metabolic rate, an increase in lean muscle mass, and an increase in serum levels of GH, IGF-1 and IGF-1 binding protein-3. A study done for the treatment of osteoporosis and bone mineral density showed increases in bone mineral density. Other possible benefits of Mk-677 are improved sleep, improved complexion, increase in energy levels, increase nitrogen retention, increase strength and an improved sense of well-being. In addition, some studies also suggest that an increased immune system response was caused by Mk-677